منابع مشابه
Peptides and peptidomimetics as prototypes.
Helma Wennemers HW received her master (Diploma) degree in chemistry from the University of Frankfurt in 1993 and her PhD degree from Columbia University New York in 1996. After two years as a postdoctoral researcher at Nagoya University, she joined the faculty at the University of Basel where she is now associate professor of chemistry. Her research focuses on the use of peptides in supramolec...
متن کاملHigh throughput synthesis of peptides and peptidomimetics.
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of ...
متن کاملPeptides and Peptidomimetics for Antimicrobial Drug Design
The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial p...
متن کاملPeptides and Peptidomimetics in Medicinal Chemistry
Peptides show great pharmaceutical potential as active drugs and diagnostics in several clinical areas such as endocrinology, urology, obstetrics, oncology, etc. and as functional excipients in drug delivery systems to overcome tissue and cellular membrane barriers (Nestor, 2009). From a pharmaceutical point of view, peptides are situated somewhere between classical organic drug substances and ...
متن کاملpeptides and peptidomimetics: their relevance in autophagy regulation in biomedicine
autophagy is a cellular process mediating degradation of bulk cytoplasm, long-lived proteins and entire organelles. in this process, double-membrane vesicles, the autophagosomes, wrap around portions of cytosol and transport them to the lysosome for degradation. several molecules participate in autophagosome nucleation and elongation, including various components of the class iii pi3k complex, ...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2008
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2008.10.015